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51st ERA-EDTA CONGRESS

 

31 May - 3 June 2014 AMSTERDAM
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Discussion forum - 51st ERA-EDTA CONGRESS
    Topic - I) Diabetes. I1) Basic research in diabetes.

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Poster: 308
Visits: 19
Title: ENDURANCE EXERCISE TRAINING SUPPRESSED CARDIAC AND RENAL DAMAGE IN DIABETIC RATS.
Authors: Luciana Jorge , Kleiton A. S. Silva, Rafael S. Luiz, Rodolfo R. Rampaso, Tatiana S Cunha, Nestor Schor.
Centre: Federal University of Sao Paulo

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ENDURANCE EXERCISE TRAINING SUPPRESSED CARDIAC AND RENAL DAMAGE IN DIABETIC RATS.

Luciana Jorge
Thread initiator
Subspeciality
Reg: 5/21/2014 1:10:00 AM
Comment# 1
Diabetes mellitus causes damage in both heart and kidneys, leading to the cardiorenal syndrome that is associated with increased complications and mortality. Additionally, it causes mitochondrial dysfunction; that is responsible for several metabolism parameters. Although the specific molecular mechanisms underlying DM are not well understood, perhaps the most important pathway regulating metabolism in muscle is mitochondrial biogenesis.The Mitofusin 2 is a important protein to mitochondrial fusion. Additionally, muscle mitochondrial metabolism is regulated by a group of morphogenesis machinery proteins which are important for mitochondrial fusion and fission events and also for their independent effects on bioenergetics. Although, exercise training is a well described method to prevent DM damages, it is not clear how exercise training influences on mitofusin 2. Also, exercise training is an interesting strategy for reversing the effects of mitochondrial dysfunction.

Comment added on 5/21/2014 1:11:00 AM 
     
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